Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 7 2 2013 06 26 Serum Level of Interleukin 17 in Patients with Erosive and Non erosive Oral Lichen Planus 91 94 10.5681/joddd.2013.016 EN Firoz Pouralibaba Zohre Babaloo Farzaneh Pakdel Marziye Aghazadeh Journal Article 10.5681/joddd.2013.016 2012 05 20 Background and aims. Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study eva-luated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus. Materials and methods. This descriptive analytical study included 24 patients with erosive oral lichen planus (EOLP), 24 patients with non-erosive oral lichen planus (NEOLP) and 24 healthy volunteered as control. Blood samples of the sub-jects underwent ELISA, using special kits, to determine serum interleukin-17 levels. Data was analyzed using with descrip-tive statistic, chi-square test, and one-way ANOVA and Tukey post-hoc test with SPSS 16 software. Results. EOLP patients showed a high level of serum IL-17 compared with NEOLP patents and control groups (EOLP=184.16 ± 12.41 pg/mL, NEOLP=106.09±10.78 pg/mL, control=15.50 ± 4.34 pg/mL, P - 0.001). Conclusion. High level of serum IL-17 in erosive oral lichen planus patients compared to the non-erosive type and healthy individuals may be the reason for higher inflammation and atrophy in the erosive type.