Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 7 2 2013 06 26 Simultaneous Replacement of Maxillary Central Incisors with CEREC Biogeneric Reference Technique: A Case Report 112 118 10.5681/joddd.2013.020 EN Gokhan Akgungor Deniz Sen Eray Bal Mutlu Özcan Journal Article 10.5681/joddd.2013.020 2012 12 25 Biogeneric Reference Technique (BRT) of the CEREC 3D v.3.8 software is an effective technique for single anterior ceramic crowns because it provides computer-controlled match of the tooth form to the contralateral tooth. BRT also enables the fabrication of two or more anterior all-ceramic crowns simultaneously. This clinical report demonstrates the clinical application of BRT for designing and milling two central incisors in one appointment using a single optical impression. After completing the virtual design of the first central incisor, it was copied and a mirror image was created. The second central incisor was designed using this replicated image and therefore a computer-controlled symmetry was obtained. The crowns were milled from monolithic feldspathic ceramic blocks and adhesively luted with dual-cured resin cement following dentin conditioning. At the two-year follow-up appointment, the restorations were intact, no adverse effects were noted, and the resultant appearance was highly satisfactory for the patient. A step-by-step protocol is described from design to cementation of these restorations.